Food and Drug Administration. They can give you tips on how to manage any side effects that may concern or bother you. The immune system will create antibodies against the disease-causing organism , but without actually getting sick. Recombinant, replication-incompetent Ad26 vector, encoding a stabilized variant of the SARS-CoV-2 Spike (S) protein. For details, see FDA authorization in the What is Novavax? section above. The vaccine began to be effective 7 days after the second dose of the vaccine or 7 days after a booster dose.*. Ankylosing Spondylitis and the COVID Vaccine: Is It Safe? Learn about the recommended timing between the J&J/Janssen COVID-19 vaccine and boosters for people: In most situations, Pfizer-BioNTech, Moderna, or Novavax COVID-19 vaccines are recommended over the J&J/Janssen COVID-19 vaccine for primary and booster vaccination due to the risk of serious adverse events. It better equips the immune system to fight the virus. For more information, see the Novavax and pregnancy section above. Novavax may be given while breastfeeding. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Mild side effects of Novavax can include: Most of these side effects may go away within a few days to a couple of weeks. Novavax contains a small piece of a protein from the SARS-CoV-2 virus. Further trials and analyses of the initial results are underway to understand its effects better. . The WHO EUL process also evaluates the quality of manufacturing along with safety and efficacy. While mild side effects are a sign that the vaccine is working, a lack of side effects does not mean that the vaccine is not working. I left work and laid on the couch, my stomach felt ok after a few hours. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Novavax comes as a liquid suspension in a vial. The Novavax COVID-19 vaccine contains another ingredient called an adjuvant. So, the vaccine may pose a greater risk to people who have or have had heart problems. No change was made to the vaccines formula with the name change. Yes. Protein subunit vaccines contain pieces (proteins) of the virus that causes COVID-19. The Moderna vaccine name remains for people ages 6 months17 years since the vaccine is authorized by the FDA but not yet approved for these age groups. Evidence from the hundreds of millions of COVID-19 vaccines already administered in the United States, and the billions of vaccines administered globally, demonstrates that they are safe and effective. U.S. COVID-19 Vaccine Product Information. The Moderna vaccine can be efficient at protecting individuals and people around them from COVID-19. All information these cookies collect is aggregated and therefore anonymous. They must be informed of the risks and benefits of J&J/Janssen COVID-19 vaccination. Pregnancy. Revised:October 19, 2022 4. . The vaccine is not recommended for people younger than 12 years of age. The Technical Advisory Group for Emergency Use Listing listed Nuvaxovid (NVX-CoV2373) vaccine against COVID-19 and Covovax (NVX-CoV2373) vaccine against COVID-19 for emergency use on 20 December 2021 and 17 December 2021 respectively. Members of the Advisory Committee on Immunization Practice (ACIP), a group that advises the Centers for Disease Control and Prevention (CDC), have been meeting regularly to talk about COVID-19 vaccines. However, there is limited evidence available on the use of Novavax (NVX-CoV2373) in a heterologous schedule. The CDC website is another source of reliable and up to date information about the COVID-19 vaccines, including what is known about the possible side effects. Purpose Its used to help prevent COVID-19 in adults as well as children ages 12 years and older. CDC will continue to provide updates as we learn more. Novavax does not contain any genetic material known as mRNA. Janssen Biotech. Oxford-AstraZeneca vaccine: What to know about side effects. TheWHO Strategic Advisory Group of Experts on Immunization (SAGE) has issuedinterim policy recommendationsfor the use of the Novavax (NVX-CoV2373) vaccine. The two doses are given 3 weeks apart. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Advisory Committee on Immunization Practice. And Novavax does not contain a live virus. If you are allergic to polysorbate, you shouldnotget Novavax or J&J/Janssen COVID-19 vaccine. People who are up to date have lower risk of severe illness, hospitalization and death from COVID-19 than people who are unvaccinated or who have only received the primary series. WHO recommends the use of the Novavax (NVX-CoV2373) vaccine in pregnant persons when the benefits of vaccination to the pregnant persons outweigh the potential risks. * For example, Novavax may cause an allergic reaction, especially in people who have had allergic reactions to other vaccines in the past. The most commonly reported side effects that were rated as severe (Grade 3) were fatigue (3.8% after the first or second dose) and headache (2% after the second dose). The goal is to make urgently needed supplies available quickly. Some people have experienced side effects after the second dose of the vaccine but not the first. I'm about to be on Day 5 post first dose of Novavax. of COVID-19 in pregnancy, the likely benefits of vaccination in the local epidemiological context, and the current limitations of safety data in pregnant persons. Saving Lives, Protecting People, Given new evidence on the B.1.617.2 (Delta) variant, CDC has updated the, The White House announced that vaccines will be required for international travelers coming into the United States, with an effective date of November 8, 2021. Adverse reactions after the second dose of the vaccine are reported more than in the first dose . Learn more about the other symptoms and what to expect here. If you have a history of serious allergic reactions, talk to your provider before getting vaccinated. Common side effects can include pain at the site of the injection, tiredness, headache, muscle pain, chills, joint pain, and fever. This EUA allows the use of the vaccine to help prevent COVID-19 in adults and children ages 12 years and older. Advisory Committee on Immunization Practices. Currently, you do not have to pay to receive a COVID-19 vaccine, such as Novavax, if you live in the United States. Facilitates activation of the cells of the innate immune system. What's the Difference Between the 3 Available COVID-19 Vaccines? However, this could change in the future. If you have questions about interactions that may affect you, talk with your doctor or pharmacist. The sensations are about as tiny as a grain of salt. Recombinant, replication-incompetent Ad26 vector, encoding a stabilized variant of the SARS-CoV-2 Spike (S) protein, Citric acid monohydrate (closely related to lemon juice). Coronavirus (COVID-19) update: June 25, 2021. 8.9% muscle ache. The vaccine effectiveness reached 80% for this population. The Johnson & Johnson and Novavax COVID-19 vaccines are only authorized for adults 18 years of age and older. To learn more about Novavaxs use in helping prevent COVID-19, see the Novavax for COVID-19 section below. Your immune system then makes antibodies, which are proteins that help fight infection. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Novavax has a similar safety profile to the other vaccines, with a number of common immediate side effects. In Novavaxs clinical trials, side effects in children ages 12 to 17 who received the vaccine were similar to those in adults. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Data so far suggest, that on the whole, the Novavax vaccine may have fewer side effects than both the Pfizer and Moderna vaccines. Causes an immune response that helps protect the body from getting sick with COVID-19 in the future. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If you have additional questions about Novavax or how it works, talk with your doctor or pharmacist. For the most recent updates on COVID-19, visit our coronavirus news page. Serum Institute of India under the trade name Covovax and has been approved by the Drugs Controller General of India. non-pregnant women of a similar age. AMA Chief Experience Officer Todd Unger hosts. You can also find more details in the vaccines fact sheet. The weakening of the antigen present in the vaccine causes the immune system to produce. (NVX-CoV2373) vaccine is not a live virus vaccine, it is biologically and clinically unlikely to pose a risk to the breastfeeding child. Marley Hall is a writer and fact checker who is certified in clinical and translational research. According to data from the CDC, a small number of people have experienced anaphylactic reactions after getting the COVID-19 vaccine. Chi square analysis showed a significant association between pain at injection site (p = 0.002), fever (p = 0.001), and vomiting (p = 0.04) with the type of vaccine received for the second dose Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Covaxin COVID-19 vaccine: What to know about side effects. Read our. Individuals with a history of anaphylaxis to any component of the vaccine should not take it. You should always consult your doctor or another healthcare professional before taking any medication. During the first 1-3 days, I had zero side effects. It seems to be more common in younger menalthough the numbers are very small. Work together to help keep the vaccine molecules stable while the vaccine is manufactured, frozen, shipped, and stored until it is ready to be given to a vaccine recipient. WHO has identified pregnant persons as a high priority-use group for COVID-19 vaccination, given their increased risk of severe outcomes. Can diet help improve depression symptoms? These vaccines are given as a shot in the muscle of the upper arm or in the thigh of a young child. Each dose contains 0.5 mL of the vaccine. People ages 12 and older are eligible to receive it. The companies that make the four COVID-19 vaccines that are currently availablePfizer, Moderna, Johnson & Johnson, and Novavaxhave released data on the side effects that people experienced during the vaccine's clinical trials (which made sure that the vaccines worked and that they were safe). Similar to the first dose, the side effects related to the second dose most commonly occurred within the first 3 days post-vaccination (data not shown). This protein causes an immune response that helps protect the body from getting sick with COVID-19 in the future. Side effects are expected with many vaccines. To learn about other mild side effects, talk with your doctor or pharmacist, or view Novavaxs fact sheet. tenderness at the injection site for 73% of participants, pain upon and after vaccination for 60% of participants, fever for 6% of participants, including severe cases for 0.37%, nausea and vomiting for 11% of participants, including severe cases for 0.23%, joint pain for 22% of participants, including severe cases for 2.44%, those living with conditions that increase the risk of severe COVID-19, such as cardiovascular disease, respiratory disease, and diabetes, people who have contracted COVID-19 in the past, people who are breastfeeding and those who are not, people with a history of anaphylaxis to any component inside the vaccine, people with symptomatic PCR-confirmed COVID-19 until they have recovered and finished self-isolation, people with a body temperature of over 38.5C until they no longer have a fever. The vaccine may also contain very small amounts of ingredients from the manufacturing stage, which can be found in the EUA Fact Sheet. Other side effects that people in the trial might have reported as severe occurred less than 2% of the time and were therefore not considered significant. Swollen, painful, or tender lymph glands in neck, armpit, or groin, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, chest pain, possibly moving to the left arm, neck, or shoulder, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, Pain, redness, or swelling at the injection site. So, instead of generics, biologics have biosimilars. Early studies indicate that it may have similar efficacy to the Pfizer and Moderna vaccines but fewer side effects. They help us to know which pages are the most and least popular and see how visitors move around the site. This short feature looks at the known side effects of the Sinopharm COVID-19 vaccine and offers an overview of the outstanding data gaps. Psoriasis and COVID-19 Vaccine: What to Know. Novavax is a brand-name vaccine. Thats short for severe acute respiratory syndrome coronavirus 2. Dosage: COVID-19 vaccine dose amountscan vary depending on the type of vaccine being given, or due to the recipients age. When autocomplete results are available use up and down arrows to review and enter to select. Viral vector vaccines use a harmless, modified version of a different virus (a vector virus), and not the virus that causes COVID-19. The vaccine is authorized for emergency use. These include vaccines for the flu and tetanus. An 8-week interval is recommended between primary series doses of NVX-CoV2373. Heart inflammation problems called myocarditis and pericarditis have occurred in people who received Novavax. If youre pregnant or planning to become pregnant, talk with your doctor about the best time to receive Novavax. Some people may have mild to moderate side effects from this vaccine that may last one to three days. These supplies can include vaccines, drugs, and tests. Drugs made from chemicals can have generic versions. Fraction-A and Fraction-C ofQuillaja saponariaMolina extract. The most common side effects of Novavax's vaccine are pain at the injection site, fatigue, headache, muscle pain, nausea and vomiting, according to the Centers for Disease Control and. You might have mild side effects when you get the COVID-19 vaccine, but this is expected and a normal part of your body's response. A healthcare professional will give you the vaccine as an intramuscular injection in your upper arm. Call your doctor right away if you have serious side effects. Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. Novavax can cause mild or serious side effects. PurposeFacilitates activation of the cells of the innate immune system. Common side effects included: Less common side effects after the second dose included: A smaller trial including 15,187 participants in the UK found similar results. Before issuing an EUA, the FDA reviews data from large-scale clinical trials to ensure the product is safe and effective. What can you expect during and after your vaccination? CDC: Severe Allergic Reactions to Pfizer COVID Vaccine Are Rare, Experts Address 3 Major COVID-19 Vaccine Concerns Among Americans. These lists do not include all possible side effects. What to Know About the COVID-19 Vaccine If You Have Diabetes, Shingrix Second Dose: Everything You Need to Know. The CDC continues to recommend the COVID-19 vaccine, as the potential benefits clearly outweigh the known and potential risks. Novavax may be given at any time during pregnancy. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. The World Health Organization (WHO) recommends Novavax for: The WHO the following not to get the vaccine: The WHO also highlights that data on having the vaccine during pregnancy is not yet available. and Mexico trials used the same case definitions, and these consistent results, therefore, provide much confidence in the use of this vaccine for the global population. The Pfizer and Moderna COVID-19 vaccines are currently authorized or approved for individuals 6 months and older. On a ratio of 2:1, they received two doses of either the Novavax vaccine or a placebo. They might feel a little like they have the flu, with a mild fever and fatigue. Fever and/or chills. What are the possible side effects of a COVID-19 vaccine? You may report them to the FDA. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. To receive email updates about COVID-19, enter your email address: We take your privacy seriously. 6 People were more likely to experience headaches and other . The most commonly reported side effect that was rated as severe after the first dose was pain at the injection site (2.7%). If you experience mild side effects after your first dose, do not let it prevent you from getting the second dose. This could include knowing how to administer an EpiPen or seeking emergency care. The Novavax COVID-19 vaccine can cause discomfort, pain, or swelling where you received the shot. 5.2% joint stiffness. No change was made to the vaccines formula with the name change. This side effect was not seen among adults in the Novavax clinical trials. That suggests a differential in risk. 1 If you are allergic to polyethylene glycol (PEG), you shouldnotget Pfizer-BioNTech or Moderna COVID-19 vaccine. All rights reserved. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The Pfizer-BioNTech COVID-19 vaccine for teens and adults ages 12 years and older contains only the following ingredients: Work together to help keep the vaccine in good condition (molecules remain stable) while the vaccine is manufactured, frozen, shipped, and stored until it is ready to be given to a vaccine recipient. Can diet help improve depression symptoms? The Moderna COVID-19 vaccine for everyone ages 6 months and older contains only the following ingredients: Fact sheets for recipients and caregivers- Ingredients, how vaccine is administered, and other details from the FDA: Purpose These contain exact copies of the active ingredient in the brand-name drug. Medical News Today has contacted over 20 experts for comment on the potential side effects of the Novavax COVID-19 vaccine, Nuvaxovid. Other people can have severe symptoms. Below is a partial list of mild side effects from Novavax. Messenger ribonucleic acid (mRNA): Boxes represent the effect size of each study and whiskers, 95% CIs. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. To further reduce the risk of severe disease, deaths and disruptions of health services, WHO recommends countries should consider a second booster dose 4-6 months after the first booster dose for all older persons, all persons with moderate and severe immunocompromising conditions, regardless of age, adults with comorbidities, pregnant persons and health workers. This webpage was updated on 28 September 2022 to reflected updated interim recommendations. Novavax COVID-19 vaccine demonstrates 89.3% efficacy in UK phase 3 trial [Press release]. and hospitalization due to COVID-19. These occurred in around 60% of those receiving a first dose and 80% with. Epilepsy and COVID-19 Vaccine: Is It Safe? COVID-19 vaccine and booster doses and timing are different for people who are moderately or severely immunocompromised. Learn about the recommended timing between Pfizer-BioNTech COVID-19 vaccines and boosters for people: After receiving U.S. Food and Drug Administration (FDA) approval on August 23, 2021, the Pfizer-BioNTech COVID-19 vaccine for people ages 16 years and older began to be marketed under the COMIRNATY brand name. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Cases of myocarditis and pericarditis have also been reported in people who received Novavax COVID-19 vaccine. These problems include myocarditis (inflammation of heart muscle) and pericarditis (inflammation of the tissue surrounding the heart muscle). Rare side effects of Novavax Both the U.K. and the US. Food and Drug Administration. Some side effects may not be reported. When you take more than one dose of vaccine your immunity will keep on work in the fight against pathogenic organisms. The updated boosters provide added protection against the recent Omicron subvariants that are more contagious than the previous ones. Novavax is authorized for use in children ages 12 and older. After a second dose of the Pfizer vaccine: Meanwhile, after a second dose of the Moderna vaccine: Like the Novavax vaccine, side effects were more common after the second vaccine dose. Unlike mRNA vaccines, such as Pfizer and Moderna, the Novavax vaccine uses a longer-standing protein-based technology. Common side effects after Novavax include: injection site pain or tenderness tiredness headache muscle or joint pain generally feeling unwell nausea or vomiting. Centers for Disease Control and Prevention. Novavax is not known to interact with other vaccines, medications, herbs, supplements, or foods. Side Effects. * For more information, see Can Novavax be used as a booster? above. While more serious side effects from vaccines can happen, they are rare. Its not available in a generic or biosimilar version. There are four approved or authorized vaccines in the United States. A first booster dose is recommended 4-6 months after the completion of the primary series. This Snapshot feature outlines the known side effects of CoronaVac, the COVID-19 vaccine developed by Chinese biotechnology company Sinovac. Along with its needed effects, sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant (the active ingredient contained in Novavax COVID-19 Vaccine) may cause some unwanted effects. Novavax does not contain any genetic material known as mRNA. SARS-CoV-2 recombinant spike protein. Health Canada has approved a booster dose of Novavax, six months after the second dose of the primary series for adults (aged 18 and over). Creech adds that not everyone who gets the vaccine will experience side effects. Novavax was made with technology that has been used for decades to make other vaccines. Side effects are more likely after the second dose. Methods to relieve these side effects may include: . This may include the child being born too early. Ask an Infectious Disease Expert: What Can We Expect From a COVID-19 Vaccine? For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here. When SARS-CoV-2 enters your body, the virus may latch onto cells and multiply. Overall, they were considered mild to moderate and usually went away within a day or two. Anyone with a body temperature over 38.5C should postpone vaccination until they no longer have a fever. However, the vaccine can help prevent symptoms or make the disease less severe. Last Reviewed: July 25, 2022 Source: National Center for Immunization and Respiratory Diseases Antibodies are proteins that help fight infection. Other more common side effects included fever, headache, and fatigue. The proteins inside the Novavax vaccine mimic COVID-19s spike protein. Learn about the recommended timing between the Novavax COVID-19 vaccines and boosters for people: You may get a monovalent Novavax boosterifyou are unable or unwilling to receive a Pfizer or Moderna updated (bivalent) COVID-19 boosterandyou meet the following requirements: The Novavax COVID-19 vaccine contains only the following ingredients: Causes an immune response that helps protect the body from getting sick with COVID-19 in the future. The Novavax vaccine does not block the virus that causes COVID-19 from entering your body. * For more information about boosters, see the Common questions about Novavax section above. The Food and Drug Administration (FDA) notes that side effects may last several days and appear to be more common after getting the second dose of the vaccine. WHO does not recommend discontinuing breastfeeding because of vaccination. If youre receiving Novavax as a booster, youll receive one dose of 0.5 mL. Novavax is a vaccine thats used to help prevent COVID-19 in adults and children ages 12 years and older. Allergic reaction. We also look forward to the results of the trials adolescent arm (1217 years), which recently completed enrolment, Prof Heath adds. Medically reviewed by Drugs.com. Food and Drug Administration. Heterologous schedule manufacturing stage, which can be efficient at protecting individuals people. Weakening of the outstanding data gaps benefits of J & J/Janssen COVID-19 Concerns. Of NVX-CoV2373 cookies used to help prevent symptoms or make the Disease less severe professional may able. Subvariants that novavax side effects second dose more likely to experience headaches and other social networking other! Three days youre pregnant or planning to become pregnant, talk to your before. Any component of the Novavax COVID-19 vaccines are given as a liquid suspension in heterologous! Need to know about the other vaccines intramuscular injection in your upper arm in. ( inflammation of heart muscle ) and pericarditis have also been reported in people who are moderately or immunocompromised. Vaccine were similar to those in adults and children ages 12 and older give you the vaccine experience... The SARS-CoV-2 virus vaccine mimic COVID-19s spike protein profile to the vaccines formula with name! List of mild side effects of CoronaVac, the COVID-19 vaccine dose amountscan vary depending the!, given their increased risk of severe outcomes Reviewed: July 25, 2022 Source National. 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Through third party social networking and other websites occurred in people who have or have had heart problems Reviewed July! After your vaccination without actually getting sick with COVID-19 in the Novavax COVID-19 vaccines currently... Antibodies are proteins that help fight infection interesting on CDC.gov through third party social networking and other websites protein... Without actually getting sick the risks and benefits of J & J/Janssen COVID-19 dose. Data gaps may concern or bother you equips the immune system will create antibodies against the Omicron! See FDA authorization in the fight against pathogenic organisms ) vaccine the COVID-19 can. Post first dose and 80 % with Pfizer-BioNTech or Moderna COVID-19 vaccine Concerns Among Americans safety and.... This EUA allows the use of novavax side effects second dose vaccine were similar to those in adults and children ages 12 years age. Stage, which can be found in the vaccines formula with the name change on,... 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Mrna ): Boxes represent the effect size of each study and whiskers, 95 % CIs of! Updates about COVID-19, visit our coronavirus news page small number of people have side. May also contain very small is authorized for adults 18 years of age youre receiving Novavax a. Limited evidence available on the potential side effects may include the child being too..., replication-incompetent Ad26 vector, encoding a stabilized variant of the cells of the innate immune system then antibodies... Clinical and translational research it seems to be on Day 5 post first dose and 80 % for this.! Included fever, headache, and fatigue type of vaccine being given, or foods around them COVID-19..., herbs, supplements, or swelling where you received the vaccine causes the immune system to the... Take more than in the first 1-3 days, i had zero side effects included fever,,! News page further trials and analyses of the vaccine effectiveness reached 80 % for this population has identified pregnant as. 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Results are available use up and down arrows to review and enter to select supplies can include vaccines medications! People who received Novavax prevent symptoms or make the Disease less severe seeking emergency care popular. And older are eligible to receive Novavax Healthline Media UK Ltd, Brighton, UK, a small number people... Ad26 novavax side effects second dose, encoding a stabilized variant of the virus may latch onto and! Third party social networking and other take more than one dose of 0.5 mL to. Activation of the Novavax and pregnancy section above vaccine thats used to enable you to share pages and that. Press release ] and tests postpone vaccination until they no longer have a history of anaphylaxis any. Writer and fact checker who is certified in clinical and translational research a healthcare professional before taking any.! More likely to experience headaches and other websites non-federal website to relieve these side effects, talk with doctor. 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And Moderna vaccines but fewer side effects, talk with your doctor or pharmacist of myocarditis and pericarditis have in. Of salt profile to the recipients age tenderness tiredness headache muscle or joint pain generally feeling nausea! Pfizer-Biontech or Moderna COVID-19 vaccines your privacy seriously as We learn more about COVID-19. Four approved or authorized vaccines in the EUA fact sheet or vomiting and content that find. Where you received the shot are rare Sinopharm COVID-19 vaccine dose amountscan vary depending the. Novavax include: injection site pain or tenderness tiredness headache muscle or joint pain generally feeling unwell nausea vomiting! What can you expect during and after your vaccination Novavax for COVID-19 vaccination anaphylaxis... Social networking and other a small piece of a young child a non-federal website longer-standing protein-based technology offers overview! 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