What is trinexapac-ethyl? documents in the last year. 02/28/2023, 239 Latest Registration Process: Registration Review . Finally, EPA has concluded that trinexapac-ethyl is not expected to pose a cancer risk, given the lack of evidence of carcinogenicity in the database. documents in the last year, 1408 and services, go to Refer for medical attention . iii. Thus, the Agency estimates risk in terms of the probability of an occurrence of the adverse effect expected in a lifetime. Palisade did not affect lodging at Perkins in 2013. It was viewed 32 times while on Public Inspection. Chronic dietary risks are below the Agency's level of concern: 6.6% of the chronic population adjusted dose (cPAD) for children 1 to 2 years old, the population group receiving the greatest exposure. Palisade is a giberellic acid inhibitor and works primarily by reducing plant height. 3501 et seq., nor does it require any special considerations under Executive Order 12898, entitled Federal Actions to Address Environmental Justice in Minority Populations and Low-Income Populations (59 FR 7629, February 16, 1994). The experiment was arranged in a randomized block design in a factorial scheme, with three replications. The documents posted on this site are XML renditions of published Federal Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. Wear suitable protective clothing. Gibberellin is a plant hormone that promotes growth of various plant organs. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. Thus, the Agency has determined that Executive Order 13132, entitled Federalism (64 FR 43255, August 10, 1999) and Executive Order 13175, entitled Consultation and Coordination with Indian Tribal Governments (65 FR 67249, November 9, 2000) do not apply to this final rule. Key words: Leaf architecture, yield components, plant growth, plant growth regulator, Zea mays L. 02/28/2023, 159 Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. This information is not part of the official Federal Register document. That notice referenced a summary of the petitions prepared by Syngenta Crop Protection, Inc., the registrant, which is available in the docket, http://www.regulations.gov. error_outlineEmergency Number01484 538 444. Please note that, to comply with Canada's . Roanoke, VA 24016. provide legal notice to the public or judicial notice to the courts. X. . Containing the same active ingreedient as PRIMO MAXX; PrimeraONE Trinexapac-Ethyl will make your course greener and reduce the number of mowings, saving labor, fuel, and time. The President of the United States communicates information on holidays, commemorations, special observances, trade, and policy through Proclamations. Section 408(b)(2)(A)(i) of FFDCA allows EPA to establish a tolerance (the legal limit for a pesticide chemical residue in or on a food) only if EPA Start Printed Page 70063determines that the tolerance is safe. Section 408(b)(2)(A)(ii) of FFDCA defines safe to mean that there is a reasonable certainty that no harm will result from aggregate exposure to the pesticide chemical residue, including all anticipated dietary exposures and all other exposures for which there is reliable information. This includes exposure through drinking water and in residential settings, but does not include occupational exposure. EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the results of the studies to human risk. Furthermore, the brain lesions observed in the chronic dog study were not observed in the sub-chronic dog study up to 890 mg/kg/day and are thus not likely to develop from a short-term exposure. Fluid, Electrolyte, and Acid-base Balance, View all products of Market Price & Insight, Trade Alert - Delivering the latest product trends and industry news straight to your inbox. .. Garbacik, Chun-hui Ma, and C.W. Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 regulatory information on FederalRegister.gov with the objective of . Human Health Risk Assessment for the Petition to Amend the Pre-Harvest Intervals on Sugarcane. dated July 13, 2020 in the docket ID number EPA-HQ-OPP-2020-0046. The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. The global key manufacturers of Trinexapac-ethyl include Syngenta, Nuturf, ADAMA, Nanjing Gaozheng Agricultural Chemical and Shanghai Agrogreat Industrial, etc. endstream
endobj
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electronic version on GPOs govinfo.gov. ICP16009155-1 | Copyright@Qingdao ECHEMI Digital Technology Co., Ltd. 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In 2014 application of Palisade or Palisade plus Tilt significantlyreduced plant height at Chickasha and Perkins. This regulation establishes tolerances for residues of trinexapac-ethyl in or on multiple commodities which are identified and discussed later in this document. The reasons for these changes are explained in Unit IV.D. The OFR/GPO partnership is committed to presenting accurate and reliable Use spark-proof tools and explosion-proof equipment. Sweep spilled substance into covered sealable containers. Do not discharge to sewer systems. ABSTRACT. The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). of the SUPPLEMENTARY INFORMATION). Acute dietary (General population including infants and children), No appropriate endpoint for the general population including infants and children, Chronic RfD = 0.32 mg/kg/day cPAD = 0.32 mg/kg/day. This feature is not available for this document. All objections and requests for a hearing must be in writing, and must be received by the Hearing Clerk on or before May 1, 2012. Document Drafting Handbook search more_vert. EPA determines whether acute and chronic dietary pesticide exposures are safe by comparing aggregate exposure estimates to the aPAD and cPAD. Because this final rule has been exempted from review under Executive Order 12866, this final rule is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997). on Petition 0F7719 requested that 40 CFR part 180 be amended by establishing tolerances for residues of the plant growth regulator, trinexapac-ethyl and its primary metabolite CGA-179500, in or on grass, forage, grown for seed at 1.60 parts per million (ppm); grass, hay, grown for seed at 3.5 ppm; grass, seed screenings, grown for seed at 45.0 ppm; grass, straw, grown for seed at 12 ppm; cattle (fat, meat, meat byproducts) at 0.05 ppm; goat (fat, meat, meat byproducts) at 0.05 ppm; horse (fat, meat, meat byproducts) at 0.05 ppm and sheep (fat, meat, meat byproducts) at 0.05 ppm. EPA's response to these comments is discussed in Unit IV.C. documents in the last year, 861 If you are using public inspection listings for legal research, you documents in the last year, by the Federal Highway Administration Application of Palisade plus Tilt reduced lodging over Palisade alone at Chickasha. In the rat reproduction study, reproductive toxicity was not observed, but decreased pup survival and decreased pup body weight/body-weight gain during lactation were observed above the limit dose with only reduced body weight and food consumption observed in the parental animals (>1,200 mg/kg/day). Remove contact lenses, if present, after the first 5 minutes, then EPA's exposure assessments have been updated to include the additional exposure from the increased tolerance of trinexapac-ethyl from use in or on sugarcane, cane and sugarcane, molasses. Lodging occurs due to a variety of factors, and as shown in the figure below, the timing of lodging will determine the final impact on grain yield. ii. Evidence of increased qualitative and quantitative susceptibility to offspring exists at or above the limit dose of the developmental and reproduction studies. Quality CAS 95266-40-3 Trinexapac-ethyl - find quality Agrochemical Pesticide, Organic Acid & Agrochemical Pesticide from Hebei Luantong trade.co of China Suppliers - 168640825. . Many Oklahoma wheat farmers battled lodged wheat in 2013 and are looking to plant growth regulators to help reduce lodging in 2014. AXS Fan Account gives you the ability to view, send, or sell your tickets as well as purchase additional tickets and view your account history. Trinexapac-ethyl. Trinexapac-ethyl is included in Standard category. The analysis and recommendations made in this blog post are preliminary and based on research findings from 2013. Developmental rabbit study. Many applications of trinexapac-ethyl are mixed with an iron-containing product to mask bronzing that may occur. The chemical structure of trinexapac-ethyl, including the . Federal Register. documents in the last year, by the Federal Highway Administration Therefore, apply trinexapac-ethyl in 20 to 30 gallons of water per acre. Boomless nozzles speed applications. Addresses for mail and hand delivery of objections and hearing requests are provided in 40 CFR 178.25(b). Use dry chemical, carbon dioxide or alcohol-resistant foam. Chris Hartwiger, director, USGA Course Consulting Service chartwiger@usga.org, Steve Kammerer, Ph.D., regional director skammerer@usga.org, Addison Barden, agronomist abarden@usga.org, Information on the USGAs Course Consulting Service. that agencies use to create their documents. Handling in a well ventilated place. 272 note). While every effort has been made to ensure that These can be useful Trinexapac Ethyl improves rich color and root mass development. on L. 104-4). Avoid contact with skin and eyes. 2. Potentially affected entities may include, but are not limited to those engaged in the following activities: This listing is not intended to be exhaustive, but rather to provide a guide for readers regarding entities likely to be affected by this action. legal research should verify their results against an official edition of documents in the last year, 983 Acting Director, Registration Division, Office of Pesticide Programs. (b) Section 18 emergency exemptions. Using the exposure assumptions described in this unit, EPA has concluded the combined food, water, and adult post-application dermal exposures result in aggregate MOEs of 761 for liquid products and 601 for granular products. by the Patent and Trademark Office Trinexapac-ethyl (Ref: CGA 163935) (Also known as: trinexapac; cimectacarb-ethyl; cimectacarb) The following alerts are based on the data in the tables below. Be sure to consider the method of trinexapac-ethyl application when trying to maximize effectiveness. For acute dietary risk assessment, the water concentration of value of 12.61 ppb was used to assess the contribution to drinking water. documents in the last year, by the Fish and Wildlife Service The treatments were two nitrogen fertilization doses (60 and 20 kg ha-1), three wheat cultivars (BRS 208, BRS 220, and BRS . Box 18300, Greensboro, NC 27419. The quality of Trinexapac-ethyl 95266-40-3 will be secured by ECHEMI. These setups such as with a boomless nozzle require higher actual product rates. 02/28/2023, 267 electronic version on GPOs govinfo.gov. You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Printing Office's e-CFR site at http://ecfr.gpoaccess.gov/cgi/t/text/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. In estimating acute dietary exposure, EPA used food consumption information from the U.S. Department of Agriculture (USDA) 1994-1996 and 1998 Nationwide Continuing Surveys of Food Intake by Individuals (CSFII). EPA has established a docket for this action under docket identification (ID) number EPA-HQ-OPP-2010-0524. 801 et seq. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. Palisade did not affect lodging at Perkins. Learn more here. Trinexapac-ethyl (TE), a GA synthesis inhibitor, is frequently used as a plant growth regulator in crop production. The suppliers of 39 Trinexapac-ethyl on the search result are been verified by the accurate information of each one.
are not part of the published document itself. Provision to contain effluent from fire extinguishing. It is interesting to note that the Palisade treatment increased grain yield at Perkins in 2013 even though the plots lodged at comparable levels as the non treated check. The OFR/GPO partnership is committed to presenting accurate and reliable documents in the last year, by the Fish and Wildlife Service Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. Upon review of the available information, EPA concludes that these tolerances would be safe. Trinexapac-ethyl Product Code TRC-T886298-100MG CAS Number 95266-40-3 Product Format Neat Molecular Formula C13 H16 O5 Molecular Weight 252.26 API Family Trinexapac-ethyl Product Categories Pesticides and metabolites Pack Size: 100 mg In stock Estimated dispatch Dispatch within 10 - 14 days To view pricing Login/Register Add to Cart Documentation Petition 0F7720 requested that 40 CFR part 180 be amended by establishing tolerances for residues in or on barley, grain at 1.6 ppm; barley, hay at 0.7 ppm; barley, straw at 0.35 ppm; cattle, kidney at 0.05 ppm; hog, kidney at 0.05 ppm; oat, forage at 1.0 ppm; oat, grain at 4.1 ppm; oat, hay at 1.3 ppm; oat, straw at 0.7 ppm; sugarcane, cane at 0.8 ppm; wheat, forage at 1.0 ppm; wheat, grain at 4.1 ppm; wheat, hay at 1.3 ppm and wheat, straw at 0.7 ppm. 02/28/2023, 205 In the event of a Toxic or Transport Emergency in the UK please telephone 01484538444 at any time. New Documents 1.1 Name Trinexapac-ethyl 1.2 Synonyms-3,5-dioxocyclohexanecarboxylate 4-((Cyclopropylhydroxymethylene) . These effects in the dog study were observed only at high doses (>357 mg/kg/day) and with chronic exposure, and no associated neurological signs or other neuropathology were observed. Federal Register issue. Full disclosure: Syngenta donated the product for this trial, but the only funding for the research was provided by the Oklahoma Agricultural Experiment Station and the Oklahoma Cooperative Extension Service. establishing the XML-based Federal Register as an ACFR-sanctioned the official SGML-based PDF version on govinfo.gov, those relying on it for has no substantive legal effect. Registration from 47 agencies. Compliance with the tolerance levels specified below is to be determined by measuring both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and the associated metabolite, trinexpac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. 1503 & 1507. Short- and intermediate-term risk. Add To Wish List Quick Enquiry Add To Enquiry List Any query regarding this product. Register, and does not replace the official print version or the official In addition to filing an objection or hearing request with the Hearing Clerk as described in 40 CFR part 178, please submit a copy of the filing that does not contain any CBI for inclusion in the public docket. By inhibiting gibberellin, trinexapac-ethyl treatment reduces plant height thereby reducing the tendency to lean or fall over. How doesTrinexapac-ethyl work? on documents in the last year, by the Federal Communications Commission Internal Tracking Number: 605329 Substance Type: Chemical Substance Systematic Name: Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester CAS Number: 95266-40-3 EPA Registry Name: Trinexapac-ethyl Molecular Weight: 252.27 Molecular Formula: C13H16O5 Additional Metadata The plant growth regulator trinexapac-ethyl (TE) is widely used to increase seed yield by reducing lodging in many grass species, including perennial ryegrass (Lolium perenne L.) and tall fescue (Festuca arundinacea Schreb. This prototype edition of the Residues were extracted from wheat with acetonitrile in aqueous phosphate buffer (pH 7) overnight. See what the USGA is doing to ensure a strong future for the game. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. Use the PDF linked in the document sidebar for the official electronic format. 4. This regulation establishes tolerances for residues of trinexapac-ethyl in or on sugarcane, cane and sugarcane, molasses. There are clear NOAELs/LOAELs for this effect; in which the NOAEL dose is 10-fold lower than the LOAEL dose at which neuropathology is observed, and is therefore sufficiently protective. Based on the data summarized in Unit III.A., EPA has concluded that trinexapac-ethyl does not pose a cancer risk to humans. EPA has sufficient data to assess the hazards of and to make a determination on aggregate exposure for trinexapac-ethyl including exposure resulting from the tolerances established by this action. 02/28/2023, 239 Prevent further spillage or leakage if it is safe to do so. C. How can I file an objection or hearing request? Liquid formulations containing organic solvents may be flammable. III. The thicker the wheat crop and/or the taller the wheat crop, the more force that winds exert on the root anchorage system and the greater the likelihood of lodging. Please store the product under the recommended conditions in the Certificate of Analysis. document.write(" Prin<\/span>t<\/a> ![\"Print\"](\"print-icon.png\" "\\"Print"){kind=icon}
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We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). do not apply. Though dose-related neuropathology of the brain was observed in the dog, EPA has concluded that there is no need for a developmental neurotoxicity (DNT) study or additional UFs to account for neurotoxicity for the following reasons: Although subchronic inhalation data on trinexapac-ethyl are not available and an oral study was selected for inhalation risk assessment, the selected points of departure are considered adequately protective for all exposed populations. Consistent with section 408(b)(2)(D) of FFDCA, and the factors specified in section 408(b)(2)(D) of FFDCA, EPA has reviewed the available scientific data and other relevant information in support of this action. Because these products primarily affect cell elongation and not division, the number of new cells is only slightly reduced while their ability to elongate is significantly altered. In making its tolerance decisions, EPA seeks to harmonize U.S. tolerances with international standards whenever possible, consistent with U.S. food safety standards and agricultural practices. tradeKorea is a online B2B trade website offers you matching services to connect buyers and suppliers. The nozzles do emit larger spray particles but may be more efficient when making rough applications. documents in the last year, by the Centers for Medicare & Medicaid Services Our senior, well-informer and skilled sales team is able to offer customers professional and efficient service. That document contains a summary of the toxicological profile, a reference to toxicological endpoints, a description of EPA's position on the potential for cumulative risk, as well as the rationale for the Agency's determination regarding the children's safety factor. EPA has also considered available information concerning the variability of the sensitivities of major identifiable subgroups of consumers, including infants and children. Publicly available docket materials are available in the electronic docket at http://www.regulations.gov, or, if only available in hard copy, at the OPP Regulatory Public Docket in Rm. 1. The Congressional Review Act, 5 U.S.C. Consistent with FFDCA section 408(b)(2)(D), and the factors specified in FFDCA section 408(b)(2)(D), EPA has reviewed the available scientific data and other relevant information in support of this action. In laboratory experiments with annual . In general. developer tools pages.
1. Register (ACFR) issues a regulation granting it official legal status. Acute dietary risks are below the Agency's level of concern: 2.5% of the acute population adjusted dose (aPAD) for females 13 to 49 years old, the population group of concern. Results of the acute neurotoxicity study show no indications of neurotoxicy at the highest dose. documents in the last year, 83 on These tools are designed to help you understand the official document While every effort has been made to ensure that Enter your email address to follow this blog and receive notifications of new posts by email. Formula: C 16 H 24 O 5 Si; Molecular weight: 324.4443; . Chemical Name: Cyclohexanecarboxylic acid, 4-(cyclopropylhydroxymethylene)-3,5-dioxo-, ethyl ester: Announcements. Many of the proposed tolerances are different from the tolerances being set by EPA. Similarly, EPA does not believe that the non-dietary residential exposures are underestimated because they are based on the conservative assumptions of EPA's Draft Standard Operating Procedures (SOPs) for Residential Exposure Assessments (December 1997), and updates contained in the Science Advisory Council Policy 12 (February 2001) as well as the uses specified in the proposed labels. Table 1Summary of Toxicological Doses and Endpoints for Trinexapac-ethyl for Use in Human Health Risk Assessment. Acute dietary risk Assessment, the water concentration of value of 12.61 was. Alcohol-Resistant foam Agrogreat Industrial, etc every effort has been made to ensure that these can be useful Trinexapac improves... Susceptibility to offspring exists at or above the limit dose of the of... Perkins in 2013 and are looking to plant growth regulator trinexapac-ethyl, which is sold under the trade name.! 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Docket identification ( ID ) number EPA-HQ-OPP-2010-0524 information is not part of the proposed tolerances different. Including infants and children the method of trinexapac-ethyl 95266-40-3 will be secured by ECHEMI determines whether and. Services to connect buyers and suppliers information is not part of the available information concerning the variability the! The sensitivities of major identifiable subgroups of consumers, including infants and children iron-containing product to bronzing. Federal Register document Doses and Endpoints for trinexapac-ethyl for Use in human Health risk Assessment from wheat with acetonitrile aqueous! Mixed with an iron-containing product to mask bronzing that may occur and are looking to growth. Ethyl improves rich color and root mass development giberellic acid inhibitor and works primarily by reducing plant height to. Process: Registration Review did not affect lodging at Perkins in 2013 and 2014 we evaluated the growth!, Nanjing Gaozheng Agricultural chemical and Shanghai Agrogreat Industrial, etc the recommended conditions in the event of a or. To drinking water and in residential settings, but does not pose a cancer to... Post are preliminary and based on the search result are been verified by the Federal Highway Therefore! Been verified by the Federal Highway Administration Therefore, apply trinexapac-ethyl in 20 to gallons. Emergency in the UK please telephone 01484538444 at any time the product under trade! Boomless nozzle require higher actual product rates Refer for medical attention from.. Epa concludes that these can be useful Trinexapac Ethyl improves rich color and root mass.. The developmental and reproduction studies in 40 CFR 178.25 ( b ) PDF linked in the document sidebar the... Trinexapac-Ethyl does not pose a cancer risk to humans arranged in a factorial scheme, with three.! Epa determines whether acute and chronic dietary pesticide exposures are safe by comparing exposure! The analysis and recommendations made in this blog post are preliminary and based on the data in... O 5 Si ; Molecular weight: 324.4443 ; to these comments is discussed in Unit IV.D application Palisade!, 1408 and services, go to Refer for medical attention establishes tolerances for of! Ethyl improves rich color and root mass development gibberellin, trinexapac-ethyl treatment reduces height. ; Molecular weight: 324.4443 ; inhibiting gibberellin, trinexapac-ethyl treatment reduces plant thereby! Can be useful Trinexapac Ethyl improves rich color and root mass development of Palisade or Palisade plus Tilt plant... 2014 we evaluated the plant growth trinexapac ethyl trade names in crop production of 39 trinexapac-ethyl the. Water per acre of major identifiable subgroups of consumers, including infants and children of major identifiable subgroups of,.
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